Question : A 40-year-old woman, who is HIV-positive, is experiencing confusion, seizures, and changes in consciousness. She is originally from France and has tested positive for Toxoplasma gondii IgG.
An MRI did not reveal any specific lesions, and a lumbar puncture was performed because there was no evidence of increased intracranial pressure. The examination of the cerebrospinal fluid (CSF) showed a positive PCR for T. gondii.
Eight months ago, her CD4 count was less than 200 cells/μL, and she was started on prophylaxis for Pneumocystis pneumonia (PCP) with co-trimoxazole. However, she developed a rash, and the medication was switched to dapsone.
What would be the recommended treatment plan?